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eukaryotic protein synthesis inhibiting compounds

A quick guide to small molecule inhibitors of eukaryotic protein synthesis


EuPSIC is a manually curated and continuously updated database of small molecules that have been shown in the literature to specifically inhibit eukaryotic translation in vivo or in vitro. The compounds are divided into three groups depending on their targets and are further classified according to structural and mechanistic features. Users are encouraged to search through the tables or download information in their preferred format.

Number of compounds in a database: 



Table 1. Inhibitors of eukaryotic ribosome


SC Name Pubchem CIDs Class, group of chemical compounds MW Domain specifi-
city (BAE)
Ribosomal subunit Binding site Stage affected Mechanism of action Effect on polysomes Comments References Clinical trials PDB structures
228m253602
pyrrolidine, anisomycin group
265AE60SPTC (A)ES
causes ribotoxic stress; shows the amino acid specificity
NA
{1K73 - archaea}, {3CC4 - archaea}, {4U3M - yeasts}, {5FCJ - yeasts}
22911790817
pyrrolidine, anisomycin group
223E60SPTC (A)E?S?
less effective than anisomycin, but does not cause ribotoxic stress
10318810NANA
1233081195
pyrrolidine, anisomycin group
318E60SPTC (A)?E?NANANANA
62neosolaniol13818797
trichothecene A
‎382E60S?PTC (A)?E?NANA3824405NA
{4U6F - yeasts}
63HT-2 toxin10093830
trichothecene A
‎424E60SPTC (A)?E?NA3824405NANA
151107974
trichothecene А
264BAE60S?PTC (A)?E?S/D856003NA
{4U53 - yeasts}
64acetyl T-2546103
trichothecene A
509E60S?PTC (A)?E?NANA3824405NA
{4U6F - yeasts}
6514218252
trichothecene A
350E60S?PTC (A)?E?NANADOI
DOI
NANA
6691518
trichothecene A
366BAE60SPTC (A)
E (early stages)
D
irreversible inhibitors slightly inhibits rna synthesis
NANA
125trichodermin20806
trichothecene A
292E60SPTCEPTC inhibitorS/D
reversible inhibitor
NANA
126trichodermol12315016
trichothecene A
250E60SPTCEPTC inhibitorSNANA
67T-2 toxin5284461
trichothecene A
467E60SPTC (A)
E (early stages)
D
irreversible inhibitor; shows the amino acid specificity
NA
{4U6F - yeasts}
68T-2 triol13797589
trichothecene A
382E60S?PTC (A)?E?NA
strong inducer of apoptosis; can activate the stress-activated kinases c-Jun N-terminal kinase 1 (JNK1) and/or p38MAPK (SAPK2)
3824405NA
{4U6F - yeasts}
152calonectrin11473563
trichothecene A
‎350NA60S?PTC (A)?EPTC inhibitorS/DNANANA
153scirpentriol73495
trichothecene A
282BAE60SPTC (A)EPTC inhibitorSNA3824405NANA
12710382483
trichothecene B
338E60S?PTC (A)?E?NANA22859312NANA
12840024
trichothecene B
296E60SPTC (A)EPTC inhibitorDNANA
{4U53 - yeasts}
129nivalenol5284433
trichothecene B
312E60S?PTC (A)?E?D
causes ribotoxic stress
4521056NA
{4U53 - yeasts}
154trichothecin12444502
trichothecene B
332E60SPTC (A)?EPTC inhibitorS/DNANANA
130304599
trichothecene B
354E60SPTCES/d
does not penetrate into the yeast cells
NA
{4U53 - yeasts}
155crotocin6437832
trichothecene С
332E60SPTC (A)E, T?S
reversible inhibitor
999905NANA
205roridin A9915017
trichothecene D
‎533E60S?PTC (A)?E?NANA3376149NA
{4U50 - yeasts}
206satratoxin G23305158
trichothecene D
545E
60S (28S)
40S
PTC (A)E?D
reversible binding to a ribosome
19306889NA
{4U50 - yeasts}
NANA
trichothecene D derivative
NAENAPTC (A)?E?NA
noval molecule, poorly studied
22806769NANA
2076326658
trichothecene D, muconomycin
NAE60SPTC (A)
E (early stages)
PTC inhibitorS/d
irreversible inhibitor
NA
{4U50 - yeasts}
20823305159
trichothecene D, muconomycin
485E60S?PTC (A)?E?PTC inhibitorS/dNANANA
21011049880
trichothecene D, muconomycin
NAE60S?PTC (A)?E?NA
noval molecule, poorly studied
22806769NANA
212443670
tetraheterocyclic alkaloid
287E60SPTC (A)EPTC inhibitor(S)NANANA
213443678
tetraheterocyclic alkaloid
317AE60SPTC (A)E(S)NANA
{5ON6 - yeasts}
214jonquailine271607
tetraheterocyclic alkaloid
345E?60S?PTC (A)?E?NA25598189NANA
1115479394
tetraheterocyclic alkaloid
307BAE?60S?PTC (A)?E?PTC inhibitorSNA
343817
275
42176
NANA
215crinamine73620
tetraheterocyclic alkaloid
301BAE60SPTC (A)E(S)NANA
112narciclasine72376
tetraheterocyclic alkaloid
293BAE60SPTC (A)ESNA
343817
275
42176
NA
{4U51 - yeasts}
216pretazettine73360
tetraheterocyclic alkaloid
331E60SPTC (A)ESNANANA
113101204
tetraheterocyclic alkaloid
309BAE?60S?PTC (A)?E?PTC inhibitorS?NA
343817
275
42176
NANA
NANA
tetraheterocyclic alkaloid
NABAE?60S?PTC (A)?E?PTC inhibitorS?NA
343817
275
42176
NANA
217441593
tetraheterocyclic alkaloid
301AE60SPTC (A)ES29429877NA
{5ON6 - yeasts}
156
tetraheterocyclic alkaloid
371BAE60SPTC (A)EPTC inhibitorNANANANA
15711876135
tetraheterocyclic alkaloid
289BAE60SPTC (A)EPTC inhibitorNANANANA
NAlycorine‎72378
tetraheterocyclic alkaloid
287BAE60SPTC (A)EPTC inhibitorNA
small effect on yeasts?
NANA
132443689
tetraheterocyclic alkaloid
289BAE60SPTC (A)EPTC inhibitorNANANA
{4U4U - yeasts}
230agelastatin A177936
heterocyclic alkaloid
341E60SPTC (A)EPTC inhibitorNANA28457705NA
{5MEI - yeasts}
133
homoharringtonine / omacetaxine mepesuccinate
285033546AE60SPTC (A)
E (early stages)
PTC inhibitorD
used in the treatment of acute leukemia
{3G6E - archaea}, {4U4Q - yeasts}, {6EK0 - humans}, {6QZP - humans}
134276389532AE60SPTC (A)
E (early stages)
PTC inhibitorD
shows the amino acid specificity
NA
{3G6E - archaea}, {4U4Q - yeasts}, {6EK0 - humans}, {6QZP - humans}
15865305315(E)60SPTC (A)?(E)?(S)
showing minimal activity
8 USANA
12415816477
nuphar alkaloid
527ENANANANANANAlink
DOI
link
NANA
1amikacin37768
aminoglycoside
586BE40SDCE, TDNA
{2F4V - bacteria}, {4P20 - bacteria}, {6YPU - bacteria}
2
guanidino-tobramycin
482108
aminoglycoside
678BE?40S
[30S]
18S (А)?
[16S]?
E?, T?D?NANANANA
159
nagilactone C
72505diterpenoid362E60SPTC (A)ED
another activity is a stop-codon-independent ribosome dissociation
NA
{4U52 - yeasts}
160
nagilactone E
72504diterpenoid348E60S?PTC (A)?E?NA
molecular docking discovered a RIOK2 protein (atypical kinases that are related to the ribosome maturation process) as a potential targets on nagilactone E
32047261NANA
54
hydrysedisobrucein-B
NAquassinoidNANANANANANANA
SMILES: O=C1OC([C@]2(CO3)C4C(O)[C@@H](O)[C@]3(C(OC)=O)C2[C@H]1C)CC([C@]4(C)C5O)C(C)=CC5=O
23484873NANA
161
11-acetylamarolide
460540quassinoid407NANANANANANANA15737686NANA
3
15-hydroxyklaineanone
21677660quassinoid545NANANANANANANA15737686NANA
55
2-hydroxysimalikalactone D
NAquassinoidNANANANANANANA
SMILES: CCC(C(O[C@@H]1C2[C@@]3(C)[C@H](O)[C@H](O)C4C2(C(OC1=O)CC5[C@]4(C)[C@H](O)[C@H](O)C=C5C)CO3)=O)C
15737686NANA
4
2-hydroxysimalikalactone D acetate
44559536quassinoidNANANANANANANANA15737686NANA
162ailantinol A460536quassinoid406NANANANANANANA15737686NANA
5ailanthinone441784quassinoid479E60S?PTC (A)?NAPTC inhibitorNA
the mechanism of action is not fully understood, it is assumed that it violates the normal functions of the ribosome; antimalarial was activity detected
2198027NANA
163ailanthone72965quassinoid376NANANANANANANA15737686NANA
209baccharinol6436238quassinoid563E60S?PTC (A)?E?NA
the mechanism of action of baccharinol has not been reported, but it is a trichothecin epoxide that likely inhibits elongation
14769948NANA
6brusatol73432quassinoid521E60S?PTC (A)E?NANA
{3G71 - archaea}
7bruceantin5281304quassinoid‎549AE60SPTC (A)ENANA
{3G71 - archaea}
8brucein D432922quassinoid410NANANANANANANA15737686NANA
9brucein E122785quassinoid412NANANANANANANA15737686NANA
164bruceanol A127805quassinoid543NANANANANANANA15737686NANA
165bruceanol B14060344quassinoid537NANANANANANANA15737686NANA
10bruceanol D70697724quassinoid549NANANANANANANA15737686NA
{3G71 - archaea}
11bruceanol E9985020quassinoid551NANANANANANANA15737686NANA
12bruceanol H10745249quassinoid551NANANANANANANA15737686NANA
136436226quassinoid711NANANANANANANA15737686NANA
146474271quassinoid711NANANANANANANA15737686NANA
156436229quassinoid769NANANANANANANA15737686NANA
16441789quassinoid683NANANANANANANA15737686NANA
17
bruceoside B
3000796quassinoid683NANANANANANANA15737686NANA
18
bruceoside D
460525quassinoid669NANANANANANANA15737686NANA
19
bruceoside E
460524quassinoid671NANANANANANANA15737686NANA
20bruceoside F6451123quassinoid755NANANANANANANA15737686NANA
56
bruceoside G
NAquassinoidNANANANANANANA
SMILES: CC1C2CC3C45COC(C(O)C(O)C5C2(C)C=C(OC6C(O)C(O)C(O)C(CO)O6)C1=O)(C(O)=O)C4C(OC(/C=C(C(C)C)\C)=O)C(O3)=O
15737686NANA
21glaucarubol225484quassinoid396NANANANANANANA15737686NANA
22441797quassinoid394NANANANANANANA6155912NANA
23158475quassinoid437E?60SPTC (A)NAPTC inhibitorNANANANA
2454602813quassinoid477E60S?PTC (A)?
E (early stages)
PTC inhibitorNANA6927363NANA
2454602813quassinoid603E60S?PTC (A)?
E (early stages)
PTC inhibitorNANA6927363NANA
135315123quassinoid541NANANANANANANANANA
57
dehydrobrucentin
NAquassinoidNANANANANANANA
SMILES:
CC1=C(C[C@@H]2[C@]34[C@@H]5[C@@H](O)[C@H](O)[C@](OC4)(C(OC)=O)[C@@H]3[C@@H](OC(/C=C(C(C)C)\C)=O)C(O2)=O)[C@]5(C)C=C(O)C1O
15737686NANA
25isobrucein B99530quassinoid481NANANANANANANA15737686NANA
95quassin65571quassinoid389E?60S?PTC (A)?E?NANANA15737686NANA
96neoquassin72964quassinoid391BAE?40S?DC?(R?)NANA15737686NANA
69
nigakihemiacetal A
441803quassinoid411NANANANANANANA15737686NANA
70
nigakihemiacetal D
182704quassinoid453NANANANANANANA15737686NANA
166
nigakihemiacetal E
102267540quassinoid395NANANANANANANA15737686NANA
71
nigakihemiacetal F
101665330quassinoid395NANANANANANANA15737686NANA
72
nigakihemiacetal L
182233quassinoidNANANANANANANANA15737686NANA
167picrasin A185611quassinoid475NANANANANANANA15737686NANA
97picrasin B12313355quassinoid376NANANANANANANA15737686NANA
73picrasin D46173860quassinoid391NANANANANANANA15737686NANA
74picrasin E182116quassinoid407NANANANANANANA15737686NANA
98picrasinol CNAquassinoidNANANANANANANA
SMILES:
O=C1C(OC)=C(C)[C@@]2(O)[C@]3(C)[C@@](OC(C2)=O)([H])C[C@]([C@@]4(C)[C@@]31[H])([H])[C@@H](C)C=C(OC)C4=O
15737686NANA
75picrasinol D101921953quassinoid409NANANANANANANA15737686NANA
58
semalikalactone D 11,12 diacetate
NAquassinoidNANANANANANANA
SMILES:
O[C@H]1[C@@]2(C)[C@@](C[C@](O3)([H])[C@]4(CO5)[C@@]2([H])[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]5(C)[C@]4([H])[C@@H](OC(C(C)CC)=O)C3=O)([H])C(C)=CC1=O
15737686NANA
26sergeolide134025quassinoid505NANANANANANA
anti-malarial drug
15737686NANA
27
semalikalactone D
15161842quassinoidNANANANANANANANA15737686NANA
28
sinjulactone A
460537quassinoidNANANANANANANANA15737686NANA
168
sinjulactone B
21148461quassinoidNANANANANANANANA15737686NANA
169
sinjulactone C
11970132quassinoidNANANANANANANANA15737686NANA
29undulatone5281311quassinoid535NANANANANANANANANA
30chaparrin441791quassinoid380NANANANANANANA15737686NANA
3173154quassinoid378NANANANANANANA6155912NANA
NANAquassinoidNAENANAENANANA6875823NANA
NANAquassinoidNAENANAENANANANANA
32
yadanzioside A
72956quassinoid685NANANANANANANA15737686NANA
33
yadanzioside B
72952quassinoid701NANANANANANANA15737686NANA
34
yadanzioside C
6436227quassinoid727NANANANANANANA15737686NANA
NA
yadanzioside D
SIDquassinoidNANANANANANANANA15737686NANA
35
yadanzioside E
460522quassinoid685NANANANANANANA15737686NANA
36
yadanzioside G
6436228quassinoid769NANANANANANANA15737686NANA
37
yadanzioside L
6436225quassinoid727NANANANANANANA15737686NANA
136
yadanzioside M
72961quassinoid705NANANANANANANA15737686NANA
38
yadanzioside N
6451089quassinoid711NANANANANANANA15737686NANA
59BJF 8NAquassinoidNANANANANANANA
SMILES: C/C(C(F)(F)F)=C\C(O[C@H]1C(O[C@]([C@]2(CO3)[C@]4([H])[C@@H](O)[C@@H](O)[C@]3(C(OC)=O)[C@]12[H])([H])C[C@@]([C@]4(C)C5)([H])C(C)=C(OC(/C=C(C(F)(F)F)/C)=O)C5=O)=O)=O
15737686NANA
60BJF 11NAquassinoidNANANANANANANA
SMILES: C/C(C(F)(F)F)=C/C(O[C@H]1C(O[C@]([C@]2(CO3)[C@]4([H])[C@@H](O)[C@@H](O)[C@]3(C(OC)=O)[C@]12[H])([H])C[C@@]([C@]4(C)C5)([H])C(C)=C(O)C5=O)=O)=O
15737686NANA
NA
D13(18)-dehydroglaucarubinone
NAquassinoidNANANANANANANANA15737686NANA
NAIBI 5NAquassinoidNANANANANANANANA15737686NANA
61IBI 12NAquassinoidNANANANANANANA
SMILES: C/C(C(F)(F)F)=C\C(O[C@H]1C(O[C@]([C@]2(CO3)[C@]4([H])[C@@H](O)[C@@H](O)[C@]3(C(OC)=O)[C@]12[H])([H])C[C@@]([C@]4(C)C5)([H])C(C)=C(O)C5=O)=O)=O
15737686NANA
170SUN 02375458870quassinoid573ENANANANANANA14769948NANA
171SUN 20715458871quassinoid545E?NANANANANANANANA
1176438494345E60SPTC (A, P)?NANANA2014963NANA
1149576961NAE60S?PTC (A, P)?NANA
the cytostatic activity of sparsomycin seems to be related to its lipophilicity: octylsparsomycin was shown to be three times as effective as sparsomycin
2014963NANA
118sparsomycin9543443‎361BAE60SPTC (A, P)ЕPTC inhibitorS
shows the amino acid specificity
NA
{1M90 - archaea}, {1NJM - bacteria}, {1NJN - bacteria}, {1VQ8 - archaea}, {1VQ9 - archaea}, {5DGE - yeasts}, {5DGF - yeasts}, {5DGV - yeasts}, {5TGM - yeasts}
1379578328377BAE60S?PTC (A,P)?NANA
believed to be a more effective anti-tumor agent than sparsomycin itself
reversible inhibitor;
binding experiments indicated that sparsomycin and its derivatives are fully competitive in their interaction with the ribosome
2014963NANA
1196436444360E60S?PTC (A, P)?NANANA2014963NA
{1M90 - archaea}, {1NJM - bacteria}, {1NJN - bacteria}, {1VQ8 - archaea}, {1VQ9 - archaea}, {5DGE - yeasts}, {5DGF - yeasts}, {5DGV - yeasts}, {5TGM - yeasts}
172MDL 191526105995NAE60SPTC (A, P)?NANANA2014963NANA
138MDL 208286438817393E60SPTC (A, P)?NANANA2014963NANA
1739576884404E60SPTC (A, P)?NANANA2014963NANA
3966365
nucleoside, pyrimidone
584BAE60SPTC (P)EPTC inhibitor(S)NA371683NANA
218amicetin28675
nucleoside, blasticidin group
619BAE60SPTCEPTC inhibitorSNA8157007NA
{6CZR - bacteria}
139arginomycin129552
nucleoside, blasticidin group
437BAE60S?PTC?E?NANA3610832NA
{1KC8 - archaea}, {4U56 - yeasts}, {4V9Q - yeasts}, {6B4V - yeasts}, {6BOH - bacteria}
219bamicetin170723
nucleoside, blasticidin group
605BAE60SPTCEPTC inhibitorNANA25522318NANA
140blasticidin S170012
nucleoside, blasticidin group
422BAE60SPTC (P)EPTC inhibitorNA
in bacteria, they inhibit elongation and termination, in eukaryotes-elongation; shows amino acid specificity
NA
{1KC8 - archaea}, {4U56 - yeasts}, {4V9Q - yeasts}, {6B4V - yeasts}, {6BOH - bacteria}
174gougerotin11226719
nucleoside, blasticidin group
443BAE60SPTCEPTC inhibitorDNANANA
231mildiomycin12850205
nucleoside, blasticidin group
515BE60SPTCEPTC inhibitorNA
antibiotic does not easily pass through the cell membrane, as occurs with other nucleoside and aminoglycoside antibiotics
2409064NANA
232nucleocidin72299
nucleoside, blasticidin group
364BE60SPTCNAPTC inhibitorNA
high active against trypanosomes;
ithere is an in vivo activity;
the mechanism is not fully understood;
NANANA
220plicacetine206175
nucleoside, blasticidin group
518BAE60S?PTC?E?NANANANA
{6CZR - bacteria}
175puromycin439530
aminoacyl-nucleoside
472BAE60SA siteED
puromycin is a structural analog of aminoacyl-tRNA
NA
{1FFZ - archaea}, {1FG0 - archaea}, {1KQS - archaea}, {1NJM - bacteria}, {1NJO - bacteria}, {1NJP - bacteria}, {1Q7Y archaea}, {1Q81 - archaea}, {1Q82 - archaea}, {1VQL - archaea}, {1VQM - archaea}, {1VQN - archaea}, {1VQO - archaea}, {1VQP - archaea}, {1VVJ - bacteria}, {1VY6 - bacteria}, {1VY7 - bacteria}, 2DPT, {3CD6 - archaea}, 3Q3D, {4L47 - bacteria}, {4L71 - bacteria}, {4LEL - bacteria}, {4LFZ - bacteria}, {4LNT - bacteria}, {4LSK - bacteria}, {4LT8 - bacteria}, {4P70 - bacteria}, {4TUA - bacteria}, {4TUB - bacteria}, {4TUC - bacteria}, {4TUD - bacteria}, {4TUE - bacteria}, {4YZV - bacteria}, {4ZSN - bacteria}, {5LYB - yeasts}, {6N9E - bacteria}, {6NDK - bacteria}, {6OTR - bacteria}, {6OXA - bacteria}, {6OXI - bacteria}
176A201A137348262
aminoacyl-nucleoside
803BAE60SA siteEPTC inhibitorNANA26028538NA
{4Z3S - bacteria}
143baciphelacin171612isocoumarin423BAENANAI?, R?NA
it does not act at the stage of attachment of the substrate to the ribosome, or during the formation of a peptide bond
DOINA
{4W2F - bacteria}, {5I4L - yeasts}
141actinobolin54688606isocoumarin300BAE60SPTCEPTC inhibitorNANA7196909NANA
14425223631isocoumarin‎424BAE40SE siteENANANA
{4W2F - bacteria}, {5I4L - yeasts}
177oosponol5324556isocoumarin220BAE?40S?NAE?NANANA9210464NANA
142bactobolin54676871isocoumarin383BAE?60SPTC (P)ENANANA
{4WT8 - bacteria}
115AHR-191131429
thiopseudourea
356BAE60S?PTC?EPTC inhibitorNANA4822728NANA
23354683011pyrroline197E60S?
[50S]
PTC (A, P)NASNANA
2343081434
cyclic peptide
823BAE?60S?
[50S]
PTC?
[A site]
E?[not D]NA6337880NANA
23542640128
cyclic peptide
711BAE40S, 60S
uS17, uL3, uL30, etc.
NANANA
the San B derivatives bound proteins from the 40S (S11) and the 60S (L3, 7, 12, 18, 23) subunits, whereas 2-tag derivative appears to primarily interact with 60S ribosomal subunits (L9, 10, 13, 17)
DOINANA
211griseoviridin11225326
cyclodepsipeptide
‎477BAE60SPTCENA
affinity to eukaryotic ribosomes is much lower than to bacterial ribosomes; the spectrum of action is comparable to that of streptogramin A
1096949
DOI
NANA
17854675761
ergoline alkaloid
336BAE60S?NAENA
competition of the toxin with the eukaryotic elongation factor EF1 and EF2,
only appears to be toxic in high concentrations
DOINANA
120doxycycline54671203
aromatic polyketide, tetracycline group
444BAE40S, 60SPET etc.E?NANANA30318461NA
121minocycline54675783
aromatic polyketide, tetracycline group
457BAE
40S? 60S?
[30S]
[16S]E?NANA
it shows a wide range of activity, including anti-inflammatory, neuroprotective and neuroprotective effects
NA
179129395
aromatic polyketide, tetracenomycin group
486BAE60SPETE?
prevents the progress of the synthesized peptide in the ribosomal tunnel?
NANA32601485NA
{6Y69 - bacteria}, {6Y6X - human}
203NA
aromatic polyketide, tetracycline group
NABAE40S, 60SPET etc.E?NANA
metalloproteins inhibitor, SMILES: NC(C1=C(O)CC(C2)[C@@](C1=O)(O)C=C(C2C3)C(C4=C3C=CC=C4O)=O)=O
NANA
122tigecycline54686904
aromatic polyketide, tetracenomycin group
586BAE40S?, 60S?NAENANA[11163189]1HNW
180doxorubicin31703
aromatic polyketide,
anthracycline group
544E?NANATNANA1277199NA
181actiphenol245940glutarimide275E60S?E site?E?NAlow activityNANA
9973396glutarimide339E60SE site?ESNA5220953NANA
NANAglutarimideNANA60S?E site?E?NA
10 times more active than cycloheximide
30802354NANA
22211669726glutarimide458E60SE (C3993)EDNANA
{4U4R - yeasts}
10091467glutarimide297E60SE site?E?SNA
{4U3U - yeasts}, {5GAK - yeasts}, {5LKS - human}, {6HD7 - yeasts}, {6TNU - yeasts}, {6Y0G - human}, {6Y2L - human}
182145721258glutarimideNABAE60S?E site?E?NANA31584271NANA
236125175glutarimide334NANAE site?E?NA
10 times more active than cycloheximide, binds irreversibly
30802354NANA
1016197glutarimide281E60SE siteESNANANA
22315940571glutarimide490E60S?E site?E?NANA20118940NANA
102naramycin B120760glutarimide281E60S?E site?NANA
stereoisomer of cycloheximid
DOINA
{5GAK - yeasts}, {6Y2L - humans}
2375351572glutarimide293E60SE site?ENANANANA
224ECA-LTMNAglutarimideNAE60S?E site?E?NA26577990NANA
NANA
labdane diterpenoid
400E60S?E site?E?NANA29064494NANA
9010549927
labdane diterpenoid
418E60SE siteES?NA16540697NA
{5TBW - yeasts}, {6HHQ - yeasts}
204NA
labdane diterpenoid
NAE60S
E site (G2794)
ES
SMILES: O=C(NC(C1)=O)[C@H]1[C@@H](C)C[C@H]([C@]2(C)[C@@](CC3[H])(C)C(C)(C)[C@@H](C)[C@@H](C)C2)C3=C
30759226NANA
94NA
labdane diterpenoid
NAENANAES
SMILES: O=C(NC(C1)=O)[C@H]1[C@@H](O)C[C@H]([C@]2(C)[C@@](C[C@@H]3OC(C)=O)([H])C(C)(C)[C@@H](Cl)[C@@H](Cl)C2)C3=C
29064494NANA
9121778723
labdane diterpenoid
426ENANAESNA29064494NANA
9221778724
labdane diterpenoid
350ENAE site?ESNA29064494NA
{5TBW - yeasts}
93127675
labdane diterpenoid
384E60SE siteES?NANA
{5TBW - yeasts}, {6HHQ - yeasts}
1456436218glycoside805E60SE siteED
another activity is a stop-codon-independent ribosome dissociation; irreversible inhibitor (see covalent bond on 4U4Z structure)
NA4U4Z
1465477653glycoside763E60S?E site?NANANA14970397NA
{4U4Z - yeasts}
10310345974504BAE60SE (C3993)ENANANA
{3I55 - archaea}
1046711419518BAE60SE (C3993)EDNANANA
183onnamide A23426006794A?E60SE siteENA
causes ribotoxic stress
15958059NANA
105pederine5381287504E60E siteES/d
causes ribotoxic stress
NA
{3I55 - archaea}
18411692946610E60SE siteENANA22827176NANA
106101627278544AE60SE siteENANA15958059NANA
14771306325373AEeEF2?NAENA23303710NANA
148100917959373AEeEF2?NAENA23303710NANA
14916040283595AE60SE siteENANA
{2OTJ - archaea}
150tedanolide5478005611A?E60SE siteENANANA
{2OTJ - archaea}
10721022479E40S?E site?E?(S)NA560858NANA
108cephaeline442195467E40S?E site?E?(S)NANA
{3J7A - plasmodium}, {6OKK - plasmodium}
109emetine10219481E40SE siteES
antiprotozoal and anthelmintic agent
NA
{3J7A - plasmodium}, {6OKK - plasmodium}
7692765377E40S, 60S?E siteENANANA
{4U55 - yeasts}
77tylocrebrine246845394B?E40S?E site?ENANANA
{4U55 - yeasts}
7892114394B?AE40SE site?ESNANA
{4U55 - yeasts}
110tubulosine72341‎476E40S, 60S?E site?ENANANANA
79DCB-3503402628410E40S?E site?ENANA23251437NANA
8057397503378E40S?E site?ENANA23251437NANA
81YXM-10960200110NAE40S?E site?ENANA23251437NANA
82YXM-11060200111NAE40S?E site?ENANA23251437NANA
23856652064NABAE40S?E site?E (I?)NANA[23702293]NANA
185pactamycin5289124559BAE40SE siteE, (I?)(D)NA
{1HNX - bacteria}, {4KHP - bacteria}, {4U4Y - yeasts}, {4W2G - bacteria}, {4W2H - bacteria}
186zaluzanin C72646
sesquiterpene lactone
246ENANAENANA6383382NANA
40123865
2-DOS aminoglycoside, 4,6-disubstituted
497BE40S, 60SDC, PETE, TDNANA
1MWL, 1NJJ, 2ET3, 3HAM, 3TD1, 4K32, 4LF4, 4LF9, 4P3S, 4U4O, 4V53, 4V55, 5C4K, 5CFT, 5IQC, 5IQG, 5NDG, 5OBM, 5U0T, 5U18, 5U19, 5U1I, 5XZ1, 5Z71, 5Z8A, 5ZEI, 6MN1, 6MN5, 6NP3, 6NTJ, 6O97
4186483
2-DOS aminoglycoside, 4,6-disubstituted
478BE60SDC, PETE, TDNANA
42netilmicin441306
2-DOS aminoglycoside, 4,6-disubstituted
476BAE?40S?DC?E?D?NADOIEU 1
4F8U, 4F8V, 5C4L, 5U08, 6BBZ, 6BC2, 6BC3, 6BC7, 6CAP, 6CAR, 6MB4, 6MN2, 6NP2
43tobramycin36294468BE?40S, 60S?DCE, TD?
irreversible inhibitor
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1KNY, 1L8T, 1LC4, 1M4D, 1M4G, 1M4I, 1N32, 1N33, 1ND4, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BUE, 2ESI, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3KP5, 3Q5R, 3SG8, 3SG9, 3T1H, 3T1Y, 3U6T, 3VET, 4DFB, 4DFU, 4DR2, 4DR4, 4EBK, 4EM0, 4EVY, 4FEU, 4FEV, 4FEW, 4FEX, 4GKH, 4GKI, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4OKN, 4P6F, 4P70, 4QB9, 4QC6, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WQL, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQB, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U0T, 5U1E, 5U1I, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6BFH, 6C5U, 6CAO, 6CAV, 6CEY, 6CTZ, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6O5U, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
44lividomycin72394762BAE?40S?DC?ENANANANA
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1KNY, 1L8T, 1LC4, 1M4D, 1M4G, 1M4I, 1N32, 1N33, 1ND4, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BEE, 2BUE, 2ESI, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3KP5, 3Q5R, 3SG8, 3SG9, 3T1H, 3T1Y, 3U6T, 3VET, 4DFB, 4DFU, 4DR2, 4DR4, 4EBK, 4EM0, 4EVY, 4FEU, 4FEV, 4FEW, 4FEX, 4GKH, 4GKI, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4OKN, 4P6F, 4P70, 4QB9, 4QC6, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WQL, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQB, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6BFH, 6C5U, 6CAO, 6CAV, 6CEY, 6CTZ, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6O5U, 6O97, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
45neomycin8378615BAE?40S?DC?(R?)NANA
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1KNY, 1L8T, 1LC4, 1M4D, 1M4G, 1M4I, 1N32, 1N33, 1ND4, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BEE, 2BUE, 2ESI, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3KP5, 3Q5R, 3SG8, 3SG9, 3T1H, 3T1Y, 3U6T, 3VET, 4DFB, 4DFU, 4DR2, 4DR4, 4EBK, 4EM0, 4EVY, 4FEU, 4FEV, 4FEW, 4FEX, 4GKH, 4GKI, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4OKN, 4P6F, 4P70, 4QB9, 4QC6, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WQL, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQB, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6BFH, 6C5U, 6CAO, 6CAV, 6CEY, 6CTZ, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6O5U, 6O97, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
46
paromomycin
165580616BE40S, 60SDC(R?)DUSA 9, EU 1
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1KNY, 1L8T, 1LC4, 1M4D, 1M4G, 1M4I, 1N32, 1N33, 1ND4, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BEE, 2BUE, 2ESI, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3KP5, 3Q5R, 3SG8, 3SG9, 3T1H, 3T1Y, 3U6T, 3VET, 4DFB, 4DFU, 4DR2, 4DR4, 4EBK, 4EM0, 4EVY, 4FEU, 4FEV, 4FEW, 4FEX, 4GKH, 4GKI, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4OKN, 4P6F, 4P70, 4QB9, 4QC6, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WQL, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQB, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6BFH, 6C5U, 6CAO, 6CAV, 6CEY, 6CTZ, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6O5U, 6O97, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
47NB12471461381581B?E40SDC?E, TNANAEU 1
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1LC4, 1M4D, 1M4G, 1N32, 1N33, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BUE, 2ESJ, 2ET4, 2ET5, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3SG8, 3T1H, 3T1Y, 3VET, 4DR2, 4DR4, 4EBK, 4EVY, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4P6F, 4P70, 4QB9, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5ZEJ, 6AZ1, 6AZ3, 6C5U, 6CAO, 6CAV, 6CEY, 6DTI, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0W, 6UN8, 7K00
48NB7471461382NAB?E40SDCE, TNANA23148581NANA
49TC00711735014485BE60S,
40S
PET, DCTNANA29208708NA
1EI2, 1FJG, 1FYP, 1I9V, 1IBK, 1IBL, 1J7T, 1KNY, 1L8T, 1LC4, 1M4D, 1M4G, 1M4I, 1N32, 1N33, 1ND4, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BEE, 2BUE, 2ESI, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3KP5, 3Q5R, 3SG8, 3SG9, 3T1H, 3T1Y, 3U6T, 3VET, 4DFB, 4DFU, 4DR2, 4DR4, 4EBK, 4EM0, 4EVY, 4FEU, 4FEV, 4FEW, 4FEX, 4GKH, 4GKI, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4OKN, 4P6F, 4P70, 4QB9, 4QC6, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WQL, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQB, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6BFH, 6C5U, 6CAO, 6CAV, 6CEY, 6CTZ, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6O5U, 6O97, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
50NB157127044574NAB?E40SDCE, TNANA27096052NANA
51NB156127044572NAB?E40SDCE, TNANA27096052NANA
52apramycin3081545540BE40S,
[30S]
18S (DC (G1408, A1491))
[16S (A1408, G1491)]
ENA
apramycin shows high activity for bacterial ribosomes and comparable selectivity for eukaryotic cytosolic ribosomes
USA 1
1YRJ, 2G5K, 2M4Q, 2OE5, 2OE8, 4AQY, 4K31, 6MN4, 7JM2
53neamine72392
2-DOS aminoglycoside, 4-disubstituted
‎322BE60S?DCE, TD?
common core component of many aminoglycosides
NA
1EI2, 1FJG, 1FYP, 1GYM, 1I9V, 1IBK, 1IBL, 1J7T, 1LC4, 1M4D, 1M4G, 1N32, 1N33, 1S3Z, 1V0C, 1VVJ, 1XMO, 1XMQ, 1XNQ, 1XNR, 2A04, 2B0Q, 2BUE, 2ESJ, 2ET4, 2ET5, 2ET8, 2F4S, 2FCX, 2FCY, 2FCZ, 2FD0, 2KXM, 2MXS, 2N0J, 2O3V, 2O3W, 2O3X, 2QIR, 2UU9, 2UUA, 2UUB, 2UUC, 2UXB, 2UXC, 2UXD, 2VQE, 2VQF, 2VQY, 3BNQ, 3BNR, 3C3Z, 3C44, 3C5D, 3C7R, 3DVV, 3SG8, 3T1H, 3T1Y, 3VET, 4DR2, 4DR4, 4EBK, 4EVY, 4GKJ, 4GKK, 4JD6, 4JYA, 4KHP, 4L47, 4L71, 4LEL, 4LF6, 4LF7, 4LF8, 4LFB, 4LFC, 4LNT, 4LSK, 4LT8, 4P6F, 4P70, 4QB9, 4TUA, 4TUB, 4TUD, 4TUE, 4V51, 4V52, 4V57, 4V5C, 4V5D, 4V5G, 4V5L, 4V5Y, 4V8C, 4V8F, 4V8J, 4V97, 4V9C, 4W29, 4WOI, 4WRA, 4WSD, 4WT8, 4X62, 4X64, 4X65, 4X66, 4XJE, 4ZC7, 5A9Z, 5AA0, 5BR8, 5CFS, 5DV4, 5EL6, 5EL7, 5IB7, 5IQD, 5IQE, 5IQR, 5NDJ, 5NDK, 5NDV, 5NDW, 5TCU, 5U0N, 5U1E, 5WNT, 5WNU, 5WNV, 5Z8K, 5ZEJ, 6AZ1, 6AZ3, 6C5U, 6CAO, 6CAV, 6CEY, 6DTI, 6E0D, 6FD2, 6JW7, 6JW8, 6MB5, 6MB7, 6MB9, 6MKN, 6MPF, 6MPI, 6NMK, 6NML, 6NMM, 6NMN, 6NP4, 6NP5, 6NTI, 6OF6, 6OJ2, 6OPE, 6ORD, 6P04, 6P06, 6P08, 6S0S, 6S0V, 6S0W, 6UN8, 7K00
NA56928061
2-DOS aminoglycoside, noncanonical compound
528BAE40S?DC(R?)SNANANA
187CDX5-129556880
phthalimide group
NANANANANA
increase the readthrough called by G418 it does not independently inhibit translation
NANA27407112NANA
225negamycin11118411
negamycin group
248BAE40S18STSNA31620232NA
{2QEX - archaea}, {4W2I - archaea}, {4WF1 - bacteria}
116TCP-1109117729068
negamycin group
402E40SNATNANA31620232NANA
22642831
negamycin group
232ENANATNANA25044534NANA
227102439777
negamycin group
345ENANATNANA25044534NANA
188
ataluren / PTC124
11219835ohhdiazoles284E60S?A site?Т?NA
the termination inhibition may be an artifact due to using luciferase as a reporter;
approved for the treatment of Duchenne myodystrophy
NA
189amlexanox2161
benzopyrans
298ENANATNANA22938201USA 3
2KOT, 4WBO, 5W5V, 6BOD, 6CQ1
239RTC204864615NANAENANATNA
a nonsense-mediated decay inhibitor; stabilizes mRNA with a nonsense mutation and promotes the synthesis of a complete copy of the protein with such mRNA
23774824NANA
190RTC21943812630NANAENANATNANA23774824NANA
191GJ0713192008NANAE
many binding sites
many binding sites
TNA
less toxic in comparison with related compounds
NANA
192GJ07243813055NANAE
many binding sites
many binding sites
TNA
less toxic in comparison with related compounds
NANA
193GJ10371748051NANAENANATNA
less toxic in comparison with related compounds
23774824NANA
242BZ16NA
thiazolidinone group
NAENANAТNA
RTC13 derivative
SMILES: COC1=CC(=CC=C1)C2CCC(CC3SC(=S)NC3=O)O2
NANA
83BZ641673734
thiazolidinone group
330ENANAТNANA21873052NA5OP9
194RTC131227681
thiazolidinone group
315E40S?
many binding sites?
[16S]
ТNANANANA
195RTC14794138
thiazolidinone group
298E
many binding sites?
NAТNA
no in vivo activity
NANA
84
QL-XII-47 / QL47
71748056QL47 group448ENANA
E (early stages)?
NANA
inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies; broad-spectrum antiviral activity
31914414NANA
85YKL-04-085137637635QL47 group492ENANAE?NANA31914414NANA
196512882macrolide1562BE60SNAENANA24189724NANA
197175985macrolide613ENANANANANANANANA
198mefloquine4046quinoline378E*60SGACENA
antimalarial drug; unique mechanism fof action similar to thiostrepton and other peptide antibiotics; binds at the landing site of translational factors
282880985UMD, 5ZNI
199daptomycin16134395
cyclic lipopeptide
1621BA?E40SeS19NANANANA28680364NA
200161484NA282E40S? 60S?NAI
blocks translation initiation by preventing the binding of the 60S ribosomal subunit to the 48S pre-initiation complex
D
resistanse is associated with changes in ribosome components
NANA
240131917NA264AE60SE siteT
inhibits the release of the nancent peptide from the polisome
NANANA2OTL
NAedeine ANANA739BAE40S, [30S]E siteI
disrupts binding or accomodation of Met-tRNA(i) in a P-site
NA
poorly penetrates into mammalian cells, there is a structure data of it's interaction with a yeast ribosome
25209664NANA
NAedeine BNANA781BAE?40S?E site?I?
disrupts binding or accomodation of Met-tRNA(i) in a P-site?
NANA1148278NANA
862794NA473BE60SNAI
disrupts binding of elF6 with 60S subunit
NANA31936702NA
87eIFsixty-44531207NA415E60SNAI
disrupts binding of elF6 with 60S subunit
D
disrupts the maturation of rRNA; eIFsixty-4 analogs (eIFsixty-1 (clofazimine) and eIFsixty-6) also disrupt the binding of eIF6 to the 60S subunit, but exhibit different cytotoxicity depending on the dose and cell type
31936702NANA
241eIFsixty-673253915NA385NA60SNAI
disrupts binding of elF6 with 60S subunit
NANA31936702NANA
201NSC111041269624NA189ENANANA
inhibits TDP2's binding to DNA without getting intercalated into DNA
NANANANA
88NSC115183411623NANAENANANANANA
did not signifcantly affect translation, the structure is currently not available
14769948NANA
89
PF-06378503 (PF8503)
138544609NA449E60S?PET?E
prevents the progress of the peptide in the ribosomal tunnel?
NA
it is highly specific to the amino acid sequence and is active against a small number of peptides
30875366NANA
202
PF-06446846 (PF846)
86271238NA434BAE60SPETE
it prevents the progress of the peptide in the ribosomal tunnel, which leads to changes in the conformation of PTC and inhibition of translocation, since the 3`-CAA end of the peptidyl-tRNA is incorrectly oriented
NA
it is highly specific to the amino acid sequence and is active against a small number of peptides
NANA

Table 2. Inhibitors of translation factors and ARSases


SC Name Pubchem CIDs Class, group of chemical compounds MW Domain specifi-
city (BAE)
Target Stage affected
(IETR)
Mechanism of action Comments References Clinical trials PDB structures
12259
triphenylmethane
422BAE
40S? tRNA? mRNA? eIF2-GTP-Met-tRNA(i)?
I, (E)
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, affects binding of mRNA, tRNA to ribosome, causes dissociation of ribosomes into separate subparticles, inhibits elongation factors
nonspecific inhibitor of protein-nucleic acid interactions; does not penetrate the cell membrane
NANA
2gallin191336
xanthenelike,
gallin/fluorescein
analog
366B?A?E
40S? tRNA? mRNA?
I, (E)
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, affects binding of mRNA, tRNA to ribosome
nonspecific inhibitor of protein-nucleic acid interactions; does not penetrate the cell membrane
627208NANA
366993triphenyl386B?A?E
40S? tRNA? mRNA? 60S? eIF2-GTP-Met-tRNA(i)?
I, (E)
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, affects binding of mRNA, tRNA to ribosome
nonspecific inhibitor of protein-nucleic acid interactions; does not penetrate the cell membrane
NANA
4NSC119889274104
gallin/fluorescein analog
650E?
eIF2-GTP-Met-tRNA(i)?
I
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, affects binding of mRNA, tRNA to ribosome (affects binding of Aa-tRNA?)
inhibits translation in vivo and in vitro
16928960NANA
5NSC119893274108
gallin/fluorescein analog
414E?
eIF2-GTP-Met-tRNA(i)?
I
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation
reversible inhibitor;
inhibits in vivo translation;
inhibits translation in vitro less effective;
NANA
628032
uridine analog
229BAE
eIF2, eEF2?, eIF2-GTP-Met-tRNA(i)?
I, E
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, elongation inhibitor (inhibits eEF2 activity on the ribosome)?
nonspecific inhibitor of protein-nucleic acid interactions
976261NANA
7histidinol776His analog141BAE
His-tRNA synthetase
E
inhibitor of His-tRNA synthetase and His biosynthesis
reversible inhibitor
4338230NA
1H3J, 1KAE, 1KMN, 2BKD, 2FPU, 4GYF, 4V8Y, 4V8Z, 5EQ8, 5VLC, 5YHT
8furanomycin73423lle analog157B?A?E
Ile-tRNA synthetase
E
Ile analog, inhibitor of Ile-tRNA synthetase
NA4861779NANA
9ribavirin37542m⁷G analog244EeIF4E?I
perhaps, in some circumstances, it can compete with the m7G-cap for binding to eIF4E?
NANANA
10447830Met analog464BAE
Met-tRNA synthetase
E
inhibitor of Met-tRNA synthetase
NANA
12AS, 1AER, 1AM0, 1AMU, 1ANK, 1AW4, 1BKX, 1C0A, 1C0A, 1CGP, 1CJA, 1CT9, 1CVJ, 1CX4, 1D4R, 1DEL, 1DGS, 1DMA, 1DS5, 1E1T, 1ECJ, 1EFP, 1EFV, 1EXD, 1EYJ, 1EYK, 1FA9, 1FBP, 1FJ9, 1FNC, 1FND, 1FPD, 1FPE, 1FPF, 1FPG, 1FPI, 1FPJ, 1FPL, 1FRP, 1FSA, 1FTA, 1FVI, 1FYD, 1G51, 1G51, 1G6N, 1GGM, 1GPH, 1GPM, 1GTS, 1H1H, 1H3D, 1HDI, 1HI3, 1HTO, 1HTQ, 1HTT, 1HW5, 1I5Z, 1I6X, 1IL2, 1J20, 1J59, 1JBR, 1JID, 1JP4, 1JWB, 1K9Y, 1KA0, 1KHT, 1KPF, 1KTG, 1KZ8, 1LB2, 1LGR, 1LPC, 1LTK, 1M5V, 1MB9, 1MC1, 1MD9, 1MDB, 1MF0, 1MF1, 1MZV, 1N78, 1NH8, 1NHK, 1NKS, 1NSY, 1NV7, 1O0B, 1O0C, 1O0O, 1O3Q, 1O3R, 1O3S, 1O3T, 1O94, 1O95, 1O96, 1O97, 1OBD, 1OBG, 1OBT, 1ORE, 1P8L, 1PG3, 1PG4, 1PGQ, 1PTW, 1PYG, 1Q43, 1Q5O, 1QB8, 1QF6, 1QGX, 1RAO, 1RAW, 1RDY, 1RDZ, 1RGK, 1RGS, 1ROR, 1RUN, 1RUO, 1RY2, 1S68, 1SES, 1SK6, 1SON, 1T6Y, 1T9G, 1TB5, 1TB7, 1TBW, 1TUU, 1U6B, 1U6P, 1U9Z, 1UA4, 1UKZ, 1UUY, 1UXN, 1UXP, 1UXU, 1UXV, 1V26, 1V8S, 1V9P, 1VD1, 1VP6, 1W0H, 1WDY, 1WLE, 1WXE, 1WXI, 1X9N, 1XFW, 1XQS, 1XV6, 1Y1P, 1YKD, 1YXU, 1YYZ, 1YZ0, 1Z5U, 1Z6S, 1Z84, 1Z8D, 1ZAU, 1ZBH, 1ZBU, 1ZJW, 1ZN8, 1ZN9, 1ZRC, 1ZRD, 1ZRE, 1ZRF, 1ZZN, 2A1T, 2A1U, 2A7X, 2A86, 2AK3, 2ART, 2BWJ, 2C38, 2C5S, 2CFM, 2CGP, 2CNQ, 2D1Q, 2D1R, 2DCL, 2DEU, 2DSD, 2ECK, 2EQA, 2F17, 2F3D, 2FJB, 2G1U, 2GCS, 2GCV, 2GJW, 2GM3, 2GMK, 2GSU, 2GXQ, 2GXS, 2GZ2, 2GZW, 2H0S, 2H0W, 2H0X, 2HBL, 2HCR, 2HO6, 2HO7, 2HOJ, 2HVS, 2I4I, 2IVS, 2IVT, 2IYP, 2J91, 2J9D, 2JB7, 2JGD, 2K0G, 2KP3, 2LSC, 2N4J, 2NSY, 2OK7, 2OOX, 2OUN, 2OUR, 2OUY, 2OWO, 2OZ6, 2P20, 2P2B, 2P2F, 2P2J, 2P2M, 2P2Q, 2PTM, 2PTQ, 2PW3, 2PZA, 2Q2T, 2Q4H, 2Q8M, 2QGA, 2QJT, 2QRC, 2QRK, 2R7M, 2R84, 2R85, 2RH6, 2RIF, 2RRC, 2UV4, 2UV6, 2UV7, 2V8Q, 2V92, 2V9J, 2VAR, 2VD6, 2VFK, 2VII, 2VNI, 2VSO, 2VSX, 2VZE, 2W4Y, 2W4Z, 2WEF, 2X3K, 2X75, 2XD0, 2XDB, 2XDD, 2XOY, 2XOZ, 2XXB, 2Y8L, 2Y8Q, 2YA3, 2YAB, 2YB1, 2YDD, 2YJ4, 2YPE, 2YQ9, 2YRX, 2YS6, 2YVO, 2ZE5, 2ZE6, 2ZE7, 2ZMF, 2ZR2, 3A7A, 3A9V, 3AHW, 3AW8, 3B1R, 3B4A, 3B6J, 3BER, 3BLW, 3BO2, 3BO3, 3BO4, 3BPZ, 3C0H, 3C1Y, 3C21, 3C85, 3CJ7, 3CJ9, 3CLP, 3CLR, 3CLS, 3CLT, 3CLU, 3CW9, 3DAH, 3DDJ, 3DHV, 3DLZ, 3DQX, 3DRW, 3E3N, 3E7W, 3E7X, 3EPS, 3EQ6, 3ERR, 3ETQ, 3FEG, 3FHJ, 3FHM, 3FI0, 3FIT, 3FIU, 3FNA, 3FWZ, 3G1Z, 3G89, 3GC0, 3GLV, 3GRU, 3GYD, 3H3U, 3HF7, 3HHN, 3HW5, 3HXY, 3I0Q, 3I54, 3IB8, 3IFA, 3IFC, 3IIN, 3IUY, 3IYD, 3J7Y, 3JQP, 3JQQ, 3JTF, 3JWP, 3KCC, 3KD6, 3KFL, 3KGD, 3KH5, 3L2P, 3L31, 3L4B, 3L9W, 3LC6, 3LCB, 3LFR, 3LFZ, 3LHH, 3LKM, 3LOQ, 3LQ3, 3LUD, 3LW7, 3M84, 3MF2, 3MUV, 3MZH, 3N10, 3N4M, 3N8H, 3NEM, 3NGN, 3NGT, 3NKV, 3NQR, 3NRN, 3NUA, 3NYO, 3NYQ, 3NYR, 3NZT, 3O0F, 3O0M, 3OCP, 3OCV, 3OCX, 3OF1, 3OGJ, 3OMF, 3OTF, 3P4E, 3PCO, 3PNA, 3PWK, 3PWS, 3PY5, 3PZC, 3Q10, 3QFO, 3QH8, 3QOP, 3R1H, 3R1L, 3R6S, 3R96, 3RA8, 3RAA, 3RDI, 3REX, 3RK0, 3RL6, 3ROJ, 3ROU, 3RPH, 3RPL, 3RPQ, 3RPZ, 3RQ2, 3RRB, 3RYP, 3RYR, 3SBX, 3SF0, 3SGI, 3SHR, 3SP1, 3SPL, 3SR0, 3SYT, 3SZG, 3SZQ, 3T4B, 3T5M, 3TDH, 3TJ7, 3TLX, 3TLZ, 3TNJ, 3TSQ, 3TTF, 3TV1, 3TW2, 3TY9, 3TYX, 3U0Z, 3U10, 3U11, 3U1B, 3UK2, 3UQ6, 3UQ8, 3UY4, 3VBF, 3VER, 3VEX, 3VGJ, 3VNR, 3VNS, 3VQX, 3W1B, 3WJR, 3WUH, 3WVR, 3X01, 3X05, 3X07, 3X09, 3X0B, 3ZET, 4A2U, 4A59, 4AJC, 4AJS, 4ATO, 4AVB, 4AVC, 4AZS, 4B8S, 4BLW, 4BRF, 4BRN, 4BRQ, 4CF7, 4CFE, 4CFF, 4CFH, 4CLP, 4CLT, 4CO4, 4CS3, 4CS9, 4CT9, 4CYD, 4D05, 4D3H, 4D56, 4D57, 4D7A, 4D7T, 4DG8, 4E6N, 4EAI, 4EAJ, 4EAL, 4EBU, 4EEI, 4EFC, 4EG3, 4EPM, 4EQ4, 4EQ5, 4EQL, 4EUM, 4EV0, 4EYS, 4FBC, 4FBH, 4FBP, 4FF4, 4FRY, 4FT8, 4FWK, 4G0Y, 4G8L, 4GA6, 4GBV, 4GBW, 4GQY, 4GTW, 4GVL, 4GWS, 4GWY, 4GWZ, 4GX4, 4GX6, 4H2S, 4H2V, 4H2W, 4H46, 4HBN, 4HE2, 4HG0, 4HV4, 4HVJ, 4HXV, 4HZF, 4I01, 4I02, 4I09, 4I0A, 4I0B, 4I5W, 4IFZ, 4IG1, 4IJN, 4IKE, 4IMY, 4INI, 4ITR, 4JZK, 4K46, 4K9A, 4K9B, 4KBF, 4KFS, 4KKE, 4KR2, 4KXP, 4LFZ, 4LI4, 4LQY, 4M0K, 4M30, 4M9D, 4MA0, 4MGI, 4MGK, 4MPO, 4MX2, 4MX3, 4NDF, 4NDH, 4NDI, 4NNJ, 4NYB, 4NYC, 4NYD, 4NYG, 4O6R, 4O81, 4O82, 4O83, 4OKE, 4OXI, 4OZL, 4P1G, 4P5J, 4P69, 4PEH, 4PLX, 4Q86, 4QAK, 4QEI, 4QFG, 4QFR, 4QFS, 4QK8, 4QK9, 4QKA, 4QLM, 4QLN, 4QSH, 4QSK, 4QX5, 4R1L, 4R1M, 4R3W, 4R78, 4R8I, 4RDH, 4RDX, 4RER, 4REW, 4RLE, 4RMO, 4RVN, 4RWW, 4S1B, 4TS5, 4TWB, 4U3N, 4UP7, 4UUW, 4V1U, 4W90, 4W92, 4WB2, 4WB3, 4WCC, 4WDA, 4WDB, 4WDF, 4WDG, 4WER, 4WFR, 4WK1, 4WW7, 4WYP, 4X44, 4X45, 4XJE, 4XTT, 4Y5Q, 4YAF, 4YAL, 4YAO, 4YAU, 4YAW, 4YB6, 4YE2, 4YED, 4YP1, 4YS2, 4YXM, 4ZCF, 4ZGL, 4ZHX, 4ZKL, 4ZMF, 4ZXI, 5AHW, 5B6H, 5B8H, 5BPH, 5BSR, 5BTX, 5BU2, 5BUS, 5BYF, 5C6C, 5CFN, 5CIZ, 5CK7, 5COT, 5D0N, 5D1F, 5D4D, 5D4N, 5D4O, 5DJH, 5DJI, 5DRK, 5DS7, 5DW8, 5DY9, 5DYJ, 5DZT, 5E6M, 5E7J, 5ED3, 5ED6, 5ERS, 5ET6, 5EY8, 5EY9, 5EYT, 5F1F, 5F1G, 5F29, 5F5X, 5F74, 5F9Y, 5FBB, 5FCB, 5FDU, 5FDV, 5G40, 5G5X, 5GJU, 5GMD, 5GME, 5GTD, 5GXD, 5GYZ, 5GZ5, 5GZW, 5IE3, 5IFI, 5IKP, 5IPP, 5ISO, 5J3U, 5JDA, 5JH2, 5JJU, 5JMV, 5JRH, 5K27, 5K85, 5K8F, 5K8S, 5K99, 5KBF, 5KJX, 5KJY, 5KKG, 5KLZ, 5KOD, 5KQ5, 5KS7, 5L3Q, 5L6V, 5L95, 5LCD, 5LDM, 5LMO, 5LWJ, 5M45, 5MKO, 5MSC, 5MSD, 5MSQ, 5MSS, 5MST, 5MSW, 5N5U, 5N9X, 5NC8, 5NRH, 5NRI, 5NX9, 5O1U, 5O3Q, 5O3R, 5O4P, 5O4Z, 5O70, 5OFU, 5OW0, 5SVB, 5SXS, 5T5T, 5T8S, 5T8T, 5TVA, 5U6P, 5U7V, 5UDT, 5UFU, 5URI, 5UXF, 5V0I, 5VEO, 5VYZ, 5VZ0, 5W10, 5WM2, 5WM7, 5WS9, 5WSB, 5WSC, 5X0B, 5X0E, 5X0F, 5X0G, 5X0J, 5X0K, 5X8F, 5XET, 5XSN, 5XSP, 5YFU, 5YFV, 5YFW, 5YFX, 5YG8, 5YG9, 5YGA, 5YZ2, 5ZBK, 5ZBL, 5ZQ4, 5ZQ7, 5ZSN, 5ZU7, 5ZWK, 6A03, 6AEK, 6AIC, 6ANG, 6AVH, 6AWA, 6AX8, 6B1U, 6B2E, 6B6H, 6BKF, 6BKG, 6BLJ, 6C9F, 6C9G, 6C9H, 6C9J, 6CFF, 6CJU, 6CVO, 6CVP, 6CVQ, 6CVR, 6CVS, 6CVT, 6CY7, 6CZM, 6D31, 6DFE, 6DT1, 6DT4, 6DZG, 6E4T, 6E4U, 6E4W, 6E5Y, 6E8O, 6EA3, 6EH2, 6EOF, 6EP0, 6ESA, 6ETD, 6ETF, 6ETH, 6EZU, 6EZU, 6F2V, 6FCL, 6FD5, 6FD6, 6FD9, 6GAX, 6GB0, 6GB4, 6GB9, 6GBC, 6GBF, 6GDR, 6GPB, 6GPO, 6GPR, 6GQU, 6GYO, 6H1B, 6H4G, 6H7E, 6HE0, 6HE2, 6HQ3, 6HQ4, 6HQ5, 6HVL, 6HVL, 6III, 6IJB, 6ITO, 6IYF, 6J53, 6J58, 6JWQ, 6JWR, 6JWT, 6JWU, 6JWW, 6JWX, 6JWZ, 6K4R, 6K5L, 6K8K, 6KBY, 6KDU, 6KJM, 6KRH, 6KSC, 6L5M, 6LN3, 6LS5, 6M11, 6MMO, 6MMQ, 6MN8, 6MV7, 6N5K, 6N5L, 6N5N, 6N5O, 6N5P, 6N5Q, 6N5R, 6N5S, 6N5T, 6NAB, 6NE7, 6NFE, 6NMM, 6NMN, 6O0W, 6O3P, 6O6Q, 6O6Y, 6O6Y, 6O6Z, 6O70, 6O70, 6OF6, 6OFB, 6OMS, 6OQQ, 6OV0, 6OZ1, 6OZV, 6P08, 6P09, 6P0A, 6P0B, 6P0C, 6P0D, 6P0E, 6P4U, 6P63, 6P6U, 6P8Q, 6PB4, 6PB5, 6PB6, 6PJW, 6PLM, 6PMH, 6PMT, 6Q1V, 6QJZ, 6QL9, 6QUL, 6R8U, 6RAR, 6RAS, 6RAU, 6RCE, 6RMS, 6RNT, 6S2U, 6SHQ, 6SI8, 6SIW, 6SIY, 6SLT, 6SQ8, 6SVS, 6SY7, 6TM4, 6U7B, 6UFH, 6UQF, 6UQG, 6VPM, 6VT1, 6VT8, 6VTE, 6W6Y, 6WFJ, 6X7U, 6XNV, 6YMI, 6YML, 7BUM, 7CBB, 7GPB, 7JME, 7RNT, 8GPB
11129856568Met analog228BAE
Met-tRNA synthetase
E
inhibitor of Met-tRNA synthetase
NA9934462NANA
12ethionine25674Met analog163BAE
Met-tRNA synthetase
I, E
inhibitor of Met-tRNA synthetase, disrupts ATP metabolism in the cell
NA6752686NA
1ABW, 1C21, 1D6S, 1F4L, 1G8S, 1INN, 1J6W, 1J6X, 1KBG, 1KQ0, 1KQ9, 1KSF, 1O9T, 1P1M, 1P7L, 1P99, 1PG2, 1Q7E, 1QQ9, 1RQR, 1TKJ, 1U1H, 1U1J, 1WKM, 1XS5, 1Y9Q, 1YJ3, 1ZUE, 2AJH, 2C5B, 2C5H, 2CIJ, 2FB3, 2GGC, 2P6S, 2Q33, 2Q6I, 2Q6L, 2QS8, 2V7X, 2VC1, 2WZ5, 2X1L, 2X1M, 3AEJ, 3AEM, 3AEN, 3AYL, 3C8F, 3F3D, 3GP4, 3GXA, 3H99, 3IIX, 3IR1, 3J81, 3JAP, 3JAQ, 3K2D, 3MX6, 3QSY, 3R8X, 3TJW, 3TQW, 3TRV, 3TRY, 3V11, 3VK3, 4EG1, 4EG4, 4EG5, 4EG6, 4EG7, 4EG8, 4EGA, 4FO8, 4GLS, 4GLU, 4IB2, 4IO6, 4JBL, 4L61, 4L65, 4MVW, 4MVX, 4MVY, 4MW0, 4MW1, 4MW2, 4MW4, 4MW5, 4MW6, 4MW7, 4MW9, 4MWB, 4MWC, 4MWD, 4MWE, 4OIJ, 4OIK, 4QFO, 4QHQ, 4QYM, 4R34, 4S27, 4U6J, 4U75, 4WCX, 4XN4, 4XO4, 4YAH, 4YTG, 4ZT2, 4ZT3, 4ZT4, 4ZT5, 4ZT6, 4ZT7, 5A1I, 5AGR, 5AGS, 5AGT, 5B6I, 5CGN, 5CGO, 5CPD, 5E68, 5ECP, 5EXK, 5FEW, 5FEX, 5FEZ, 5FF0, 5GOY, 5HHD, 5HR6, 5HR7, 5I1N, 5I1O, 5I1P, 5I1S, 5I5A, 5I5B, 5INX, 5IQR, 5J58, 5J59, 5J5A, 5JB3, 5JBH, 5LTX, 5NFH, 5TGS, 5TH5, 5TQU, 5TSU, 5TU6, 5URB, 5V1T, 5V49, 5VSM, 5XPK, 5YOH, 5YOI, 5YPD, 5YR7, 5YXF, 6AHI, 6BV4, 6CML, 6CNU, 6DZX, 6FD2, 6FYX, 6FYY, 6GSM, 6GSN, 6GYP, 6HTK, 6HTM, 6HTO, 6I8C, 6JF1, 6JV7, 6KP1, 6MES, 6OJA, 6PHM, 6PHN, 6PHQ, 6R8A, 6SPO, 6SPQ, 6SW9, 6SWC, 6SWX, 6TDO, 6TDQ, 6VD0, 6VE8, 6WDE, 6WOO, 6XI9, 7CCG
13352864Met analog164BE
Met-tRNA synthetase
E
inhibitor of Met-tRNA synthetase
NA9934462NANA
14gallein73685
fluorescein/gallin analogs
648E?I?
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation, affects binding of mRNA, tRNA to ribosome
NA14769948NANA
15NSC119910274122
fluorescein/gallin analogs
370E?
40S? tRNA? mRNA?
I, E?NA14769948NANA
16NSC119911274123
fluorescein/gallin analogs
314E?
40S? tRNA? mRNA?
I, E?NA14769948NANA
17NSC119913274125
fluorescein/gallin analogs
394E?
40S? tRNA? mRNA?
I, E?NA14769948NANA
18NSC119915274127
fluorescein/gallin analogs
316E?
40S? tRNA? mRNA?
I, E?NA14769948NANA
19NSC37813916212338
fluorescein/gallin analogs
532E?
40S? tRNA? mRNA?
I, E?
inhibitor of eIF2-GTP-Met-tRNA(i) complex formation and/or inhibit 43S preinitiation complex formation
NA14769948NANA
20CM16910172
beta-carboline
252EeIF1AX, eIF3I
inhibits the activity of initiator factors eIF1AX and eIF3?
NA28322844NANA
21ternatin5459184
diterpene alkaloid
‎374EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NA26651998NANA
22ochratoxin A442530isocoumarin404BAE
Phe-tRNA synthetase
E
inhibitor of Phe-tRNA synthetase
NA22069596NANA
23pateamine A10053416macrodiolide556EeIF4AI
inhibits the binding of eIF4A to eIF4G, promotes the formation of a stable complex of eIF4A with eIF4B
suppresses cap-dependent and eIF4G-dependent IRES-directed translation initiation and promotes the formation of stress granules
NANA
24456511
nucleoside amidophosphite
473E
Pro-tRNA synthetase?
E
inhibitor of Pro-tRNA synthetase
NA12678775NA1H4S, 2I4M
2511499245oxaboroles152E
Leu-tRNA synthetase
E
inhibitor of Leu-tRNA synthetase
NA21856301USA 6NA
26borrelidin6436801polyketide490BAE
Thr-tRNA synthetase
E
selective inhibitor of Thr-tRNA synthetase
NA25824639NANA
2752952025polyketide489E(eIF2)I
presumably, it binds to the initiator factor eIF2 and affects its activity?
NA30063768NANA
285377963polyketide538BAEtRNAE
with high affinity binds almost all tRNAs, inhibiting their aminoacylation
NA9257649NANA
299939559polyketide661E
Ile-tRNA synthetase
E
inhibitor of Ile-tRNA synthetase
effective against mature osteoblasts
NANA
3011848157polyketide503E
Ile-tRNA synthetase
E
inhibitor of Ile-tRNA synthetase
NA17929337NANA
31arnamial44557095
polyketide-sesquiterpene
449EeEF2NAfungicide31042251NANA
32DDD10749871748268
quinoline derivative
581NAeEF2E
antimalarial drug
26085270USA 2NA
33sordarin485851sordarin493E*eEF2E
11158355
12692531 (complex with eEF2)
9452424
973
6549
NANA
34GW 471552216471
sordarin derivatives
472E*eEF2Efungicide11600368NANA
35GW 471558101143375
sordarin derivatives
472E*eEF2Efungicide11600368NANA
36GW 479821101143570
sordarin derivatives
552E*eEF2Efungicide11600368NANA
37GW 515716101143571
sordarin derivatives
486E*eEF2Efungicide11600368NANA
38GW 570009101143572
sordarin derivatives
484E*eEF2Efungicide11600368NANA
39GW 587270132472117
sordarin derivatives
506E*eEF2Efungicide11600368NANA
40470278
sesquiterpene
295EeIF4AI
inhibits eIF4A ATP-activity
NA28757063NANA
41elisabatin A397069
sesquiterpene
310EeIF4AI
inhibits eIF4A ATP-activity
NA28757063NANA
42hippuristanol9981822steroid463EeIF4AI
inhibits eIF4A; allosteric inhibitor; blocks eIF4AI in a closed state, preventing its transition to the open state required for eIF4AI's helicase activity
exhibits antiviral activity, potential anticancer drug
27335721NANA
43fusidic acid3000226steroid516BA(E)(eEF2)E
inhibits GTP-eEF2-dependent translocation? (probably, nonspecific)
NA171159
1Q23, 1QCA, 2VUF, 4V5F, 4V5M, 4V5N, 4V7B, 4V8U, 4V9L, 4V9M, 4W29, 4WQF, 5JMN, 6Q4N, 6Q4O, 6Q4P
445251303
polyketide-sesquiterpene
312EeEF2NAfungicide31042251NANA
45febrifugine115723
quinazolinone alkaloid
301NA
Pro-tRNA synthetase
E
inhibitor of Pro-tRNA synthetase
NA22327401NANA
46halofuginone400772415NA
Pro-tRNA synthetase
E
inhibitor of Pro-tRNA synthetase
anti-inflammatory and antiprotozoal agent
22327401NA
4HVC, 4K88, 4OLF, 4Q15, 4YDQ, 5F9Z, 5XIO, 5XIP, 5XIQ, 5ZNJ, 6MN8, 6UYH
47439647
chloromethyl ketone
352BAE?eEF1A?E
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
[binds to bacterial Ef-Tu and inhibits binding activity for Aa-tRNA]
NA[DOI]NANA
48bouvardin429598773EeEF2E
blocks eEF2 dissociation from the ribosome
NANANA
4913361282
cyclic peptides, bouvardin groups
757E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
50125769
cyclic peptides, bouvardin groups
787E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
51RA I14390137
cyclic peptides, bouvardin groups
773E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
76RA IINA
cyclic peptides, bouvardin groups
NAE?eEF2?E
blocks eEF2 dissociation from the ribosome?
SMILES: O=C1[C@H]2CC(C=C3)=CC=C3CC4=C(C)C=CC(C[C@H](C(N[C@H](C)C(N[C@H](C)C(N(C)[C@@H](C(N[C@H](C)C(N2C)=C)=O)CC5=CC=CC=C5)=O)=O)=O)N1C)=C4
7922127NANA
52RA III14390141
cyclic peptides, bouvardin groups
787E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
77RA IVNA
cyclic peptides, bouvardin groups
NAE?eEF2?E
blocks eEF2 dissociation from the ribosome?
SMILES: O=C1[C@H]2CC(C=C3)=CC=C3CC4=C(C)C=CC([C@H](O)[C@H](C(N[C@H](C)C(N[C@H](C)C(N(C)[C@@H](C(N[C@H](C)C(N2C)=C)=O)CC5=CC=C(C)C=C5)=O)=O)=O)N1C)=C4
7922127NANA
4913361282
cyclic peptides, bouvardin groups
757E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
NARA VINA
cyclic peptides, bouvardin groups
NAE?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
53RA VII3034401
cyclic peptides, bouvardin groups
771E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
54RA VIII101450177
cyclic peptides, bouvardin groups
801E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
NARA IXNA
cyclic peptides, bouvardin groups
NAE?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
55RA X6444175
cyclic peptides, bouvardin groups
829E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
56RA XI131676023
cyclic peptides, bouvardin groups
815E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
57RA XII14033269
cyclic peptides, bouvardin groups
919E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
58RA XIII60208884
cyclic peptides, bouvardin groups
977E?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
NARA XIVNA
cyclic peptides, bouvardin groups
NAE?eEF2?E
blocks eEF2 dissociation from the ribosome?
NA7922127NANA
59SVC11210055891NAE?eEF2?NANA31911553NANA
60GM193663477019
cyclic diterpene glycoside, sordarin analog
503E*eEF2E
fungicide, no effect on mammals
NANA
6149867325
cyclic diterpene glycoside, sordarin analog
691E*eEF2EfungicideNA2NPF
62GR1354026444409
cyclic diterpene glycoside, sordarin analog
601E*eEF2E
fungicide, no effect on mammals
NANA
639812534
cyclic peptide
1110EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
anti-cancer agent
27713531USA 7, EU 85LZS
64didemnin B122651
cyclic peptide
1112EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
does not inhibit the delivery of aminoacyl-tRNA
NA5LZS
65122204196
cyclic peptide
817EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANANA
6611073155
cyclic peptide
1056EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANA5LZS
6710724794
cyclic peptide
1042EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANA5LZS
68cytotrienin A11966097
cyclic peptide
649EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
causes ribotoxic stress
20943818NANA
695282069
cyclic peptide, ansamycin
637E*eEF1AE?
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NA21448188NANA
706447675
cyclic peptide, ansamycin
639EeEF1AE
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANANA
7170681187
cyclic peptide, ansamycin
NANAeEF1A?NA
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis?
a novel analogue of trienomycin; anticancer activity
22162786NANA
726438814
cyclic peptide, ansamycin
623EeEF1A?E
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANANA
73139590120
cyclic peptide, ansamycin
NANANANA
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis?
a novel analogue of trienomycin; anticancer activity
30132670NANA
74139590121
cyclic peptide, ansamycin
NANANANA
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis?
a novel analogue of trienomycin; anticancer activity
30132670NANA
75139590122
cyclic peptide, ansamycin
NANANANA
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis?
a novel analogue of trienomycin; anticancer activity
30132670NANA
76trierixin24180439
cyclic peptide, ansamycin
685EeEF1A?E
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANANA
77102596141
cyclic peptide, ansamycin
683EeEF1A?E
stabilize eEF1A comples with Aa-tRNA on a ribosome after GTP hydrolysis
NANANA
784E1RCat78357788NA479EeIF4E-eIF4GI
binds to the initiator factor eIF4E and inhibits the formation of a complex with eIF4G
NA21191102NANA
794E2RCat2287236NA456EeIF4E-eIF4GI
binds to the initiator factor eIF4E and inhibits the formation of a complex with eIF4G
NA21507972NANA
804EGI-15717952NA451EeIF4E-eIF4GI
binds to the initiator factor eIF4E and inhibits the formation of a complex with eIF4G
NA17254965NANA
81rocaglamide331783NA506EeIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA, inhibiting the eIF4A helicase activity
NANA5ZC9
91WDG57-591NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)[C@H](O)[C@H](C(N(C)OC)=O)[C@H]3C5=CC=CC=C5)=CC(OC6O[C@@H]([C@@H](CO)O)CO[C@H]6OC)=C1
30504817NANA
92
CMLD012073
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(C)=N[C@@]12O)C1=CC=C(OC)C=C1
30504817NANA
93SDS-1-0-21NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(Br)C=C1)C=C(OC)C=C3OC
30504817NANA
94WDG57-590NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NOC)=O)[C@H]3C5=CC=CC=C5)=CC(OC6O[C@@H]([C@@H](CO)O)CO[C@H]6OC)=C1
30504817NANA
95
CMLD010510
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H](O)[C@H](C(N(C)OC)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
30504817NANA
96
CMLD012072
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)C1CC1)C1=CC=C(OC)C=C1
30504817NANA
97
CMLD012150
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)C1=CSC(C)=N1)C1=CC=C(OC)C=C1
30504817NANA
98
CMLD012118
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)N1CCOCC1)C1=CC=C(OC)C=C1
30504817NANA
99
BUCMD00209
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC2=C(C(OC)=C1)[C@]1(O)C3=C([C@@H](C4=CC=CC=C4)[C@@]1(O2)C1=CC=C(Br)C=C1)C(=O)N1CCC[C@H]1N3
30504817NANA
100
BUCMD00211
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC2=C(C(OC)=C1)[C@]1(O)C3=C([C@@H](C4=CC=CC=C4)[C@@]1(O2)C1=CC=C(Br)C=C1)C(=O)N1CCC[C@H]1O3
30504817NANA
101
CMLD010511
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H](O)[C@H](C(OC)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
30504817NANA
102
CMLD010513
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NOC)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
30504817NA5ZC9
103
CMLD012108
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)C1=C([C@H]2C2=CC=CC=C2)C(=O)N2CCC[C@H]2N1CCN(C)C
30504817NANA
104
CMLD012151
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1
30504817NANA
105RHTNArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)[C@H](O)[C@H](C(N(C)OC)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
30504817NA5ZC9
106
CMLD010514
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: [H]O[C@@H]1[C@@H]([C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@]12O[H])C1=CC=C(OC)C=C1)C(=O)N([H])OCCOCCOCCN=[N+]=[N-]
30504817NANA
107
CMLD012152
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)C1=CC=CN=C1)C1=CC=C(OC)C=C1
30504817NANA
108CR-1-31-bNArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(OC)C=C1)C=C(OC)C=C3OC
30504817NANA
109
CMLD010482
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC(F)=CC2=C1[C@]1(O)C3=C([C@@H](C4=CC=CC=C4)[C@@]1(O2)C1=CC=C(Br)C=C1)C(=O)N1CCC[C@@]1(C)N3
30504817NANA
110
CMLD011410
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: O[C@@]12[C@@]([C@H](C3=CC=CC=C3)[C@@H](C(C4=C(OC)C=CC=C4)=O)[C@H]2O)(C5=CC=C(OC)C=C5)OC6=CC(OC)=CC(OC)=C61
30504817NANA
111
CMLD010335
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(Br)C=C1)C=C(F)C=C3OC
30504817NA5ZC9
112
CMLD010535
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: [H]OC12C3=C([C@@H](C4=CC=CC=C4)[C@@]1(OC1=CC(OC)=CC(OC)=C21)C1=CC=C(OC)C=C1)C(=O)N1CCC[C@@]1([H])O3
30504817NANA
113
CMLD011408
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: O[C@@]12[C@@]([C@H](C3=CC=CC=C3)[C@@H](C(C4=CC5=C(C=CC=C5)O4)=O)[C@H]2O)(C6=CC=C(OC)C=C6)OC7=CC(OC)=CC(OC)=C71
30504817NANA
114
CMLD010503
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)C1=C([C@H]2C2=CC=CC=C2)C(=O)N2CCC[C@H]2N1
30504817NANA
115
CMLD010536
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)[C@H](O)[C@@H]([C@H]2C1=CC=CC=C1)C(=O)C1=CC=CO1
30504817NANA
116
CMLD011404
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: O[C@@]12[C@@]([C@H](C3=CC=CC=C3)[C@@H](C(C4=CC=C(C)O4)=O)[C@H]2O)(C5=CC=C(OC)C=C5)OC6=CC(OC)=CC(OC)=C61
30504817NANA
117
CMLD005522
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NOC)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
30504817NANA
118
BUCMD00003
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(Br)C=C1)C=C(O)C=C3OC
30504817NANA
119
CMLD010512
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: [H]O[C@@H]1[C@@H]([C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@]12O[H])C1=CC=C(OC)C=C1)C(=O)N([H])CCCC(OC)OC
30504817NA5ZC9
120
BUCMD00210
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC2=C(C(OC)=C1)[C@]1(O)C3=C([C@@H](C4=CC=CC=C4)[C@@]1(O2)C1=CC=C(Br)C=C1)C(=O)N1CCC[C@@H]1N3
30504817NANA
121
CMLD010338
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]23O)C2=NOC(C)=N2)C2=CC=CC=C2)C2=CC=C(Br)C=C2)=CC(F)=C1
30504817NANA
122
CMLD011886
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)[C@H](O)[C@@H]([C@H]2C1=CC=CC=C1)C(O)=O
30504817NANA
123
CMLD012075
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@@H]1[C@@H](C2=CC=CC=C2)[C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]22NC(=N[C@@]12O)C1=CC=CC=C1)C1=CC=C(OC)C=C1
30504817NANA
124
CMLD012049
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)[C@@H](O)[C@@H]([C@H]2C1=CC=CC=C1)C(=O)C1=CC=CO1
30504817NANA
125
CMLD011353
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: [H][C@@]12CCCN1C(=O)C1=C(N2)[C@@]2(O)C3=C(C[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(Br)C=C1)C=C(F)C=C3OC
30504817NANA
126
CMLD012187
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)[C@H](O)[C@@H]([C@H]2C1=CC=CC=C1OC)C(=O)C1=CC=CO1
30504817NANA
127
CMLD009433
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)C5=C(C(O)=NN5)[C@H]3C6=CC=CC=C6)=CC(OC)=C1
30504817NANA
128
CMLD010500
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H]5[C@H](C(O5)=O)[C@H]3C6=CC=CC=C6)=CC(OC)=C1
30504817NANA
129
CMLD012107
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)C1=C([C@H]2C2=CC=CC=C2)C(=O)N2CCC[C@H]2N1C
30504817NANA
130
CMLD011406
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: O[C@@]12[C@@]([C@H](C3=CC=CC=C3)[C@@H](C(C4=CC=C(CCC)O4)=O)[C@H]2O)(C5=CC=C(OC)C=C5)OC6=CC(OC)=CC(OC)=C61
30504817NANA
131
CMLD012186
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CON(C)C(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1OC)C1=CC=C(OC)C=C1)C=C(OC)C=C3OC
30504817NA5ZC9
132
CMLD010336
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]23O)C2=NC(C)=NO2)C2=CC=CC=C2)C2=CC=C(Br)C=C2)=CC(F)=C1
30504817NANA
59
CMLD011610 (RHT)
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: CON(C)C(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(OC)C=C1)C=C(OC)C=C3OC
30504817NA5ZC9
134
CMLD011891
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC(=O)[C@H]1[C@@H](O)[C@@]2(O)C3=C(O[C@]2([C@@H]1C1=CC=CC=C1)C1=CC=C(Br)C=C1)C=C(O)C=C3OC
30504817NANA
135
CMLD011885
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC=C(C=C1)[C@@]12OC3=CC(OC)=CC(OC)=C3[C@]1(O)[C@H](O)[C@@H]([C@H]2C1=CC=CC=C1)C(O)=O
30504817NANA
136FL3NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=CC2=C(C(OC)=C1)[C@]1(O)[C@H](O)C[C@@H](C3=CC=CC=C3)[C@@]1(O2)C1=CC=C(Br)C=C1
30504817NANA
137
CMLD011407
NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: O[C@@]12[C@@]([C@H](C3=CC=CC=C3)[C@@H](C(C4=NC=CN4C)=O)[C@H]2O)(C5=CC=C(OC)C=C5)OC6=CC(OC)=CC(OC)=C61
30504817NANA
138NArocaglatesNAE?eIF4AI
inhibits eIF4A; stabilizes the eIF4A complex with RNA?
SMILES: COC1=C2C(O[C@]3(C4=CC=C(OC)C=C4)[C@@]2(O)C5=C(C(O)=NN5)[C@H]3C6=CC=CC=C6)=CC(OC)=C1
30504817NANA
82silvestrol11787114rocaglates655EeIF4AI
inhibits eIF4A helicase activity
NANANA
83
GC7 / N1–guanyl–1,7–diaminoheptane
448393
spermidine analog
172BAEDHPS/eIF5AI
inhibitor of deoxyhypusine synthase (DHPS), which necessary for the synthesis of hypusine and posttranslational modification of eIF5A
NA25218134NANA
84
CNI1493 / semapimod
5745214anilide745EDHPS/eIF5AE
inhibitor of deoxyhypusine synthase (DHPS), which necessary for the synthesis of hypusine and posttranslational modification of eIF5A
anti-inflammatory, antimalarial drug
18256853USA 4NA
85
deoxyspergualin / gusperimus
55362
N-acil-aminoacid
388EDHPS/eIF5AE
inhibitor of deoxyhypusine synthase (DHPS), which necessary for the synthesis of hypusine and posttranslational modification of eIF5A
NA11964177USA 4, EU 2NA
NADHSI-15NANANAEDHPS/eIF5AE
inhibitor of deoxyhypusine synthase (DHPS), which necessary for the synthesis of hypusine and posttranslational modification of eIF5A
NA22415796NANA
86
ciclopirox / loprox
2749
pyridone derivative
207EDOHH/eIF5AE
inhibitor of the synthesis of hypusin which is nessary for the operation of eIF5A (iron chelator)
NANA
87deferiprone2972
pyridone derivative
139EDOHH/eIF5AE
inhibitor of the synthesis of hypusin which is nessary for the operation of eIF5A (iron chelator)
NANA
88mimosine3862
pyridone derivative
198EDOHH/eIF5AE
inhibitor of the synthesis of hypusin which is nessary for the operation of eIF5A (iron chelator)
NA30208826NANA

Table 3. Inhibitors of the main signaling pathways regulating protein biosynthesis in eukaryotic cells


SC Name Pubchem
CIDs
Class, group of chemical compounds MW Target Stage affected
(IETR)
Mechanism of action Comments References Clinical trials PDB structures
21rapamycin / sirolimus5284616macrolide914
mTORC1 (FKBP12)
I, (E)
allosteric mTOR inhibitor (mTORC1 only); 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA12742462
1C9H, 1FAP, 1FKB, 1FKL, 1NSG, 1PBK, 1Z58, 2DG3, 2DG4, 2DG9, 2FAP, 2VCD, 3KZ7, 4DH0, 4DRH, 4DRI, 4DRJ, 4QT2, 4QT3, 5FLC, 5GPG, 5HKG, 6L3A, 6M4U, 6M4V, 6M4W
22everolimus6442177
macrolide, synthetic analog of rapamycin
958
mTORC1 (FKBP12)
I, (E)
allosteric mTOR inhibitor (mTORC1 only); 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA19860903
1C9H, 1FAP, 1FKB, 1FKL, 1NSG, 1PBK, 1Z58, 2DG3, 2DG4, 2DG9, 2FAP, 2VCD, 3KZ7, 4DH0, 4DRH, 4DRI, 4DRJ, 4QT2, 4QT3, 5FLC, 5GPG, 5HKG, 6L3A, 6M4U, 6M4V, 6M4W
23temsirolimus6918289
macrolide, synthetic analog of rapamycin
1030
mTORC1 (FKBP12)
I, (E)
allosteric mTOR inhibitor (mTORC1 only); 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA19860903
1C9H, 1FAP, 1FKB, 1FKL, 1NSG, 1PBK, 1Z58, 2DG3, 2DG4, 2DG9, 2FAP, 2VCD, 3KZ7, 4DH0, 4DRH, 4DRI, 4DRJ, 4QT2, 4QT3, 5FLC, 5GPG, 5HKG, 6L3A, 6M4U, 6M4V, 6M4W
24ridaforolimus11520894
macrolide, synthetic analog of rapamycin
990
mTORC1 (FKBP12)
I, (E)
allosteric mTOR inhibitor (mTORC1 only); 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA19860903
1C9H, 1FAP, 1FKB, 1FKL, 1NSG, 1PBK, 1Z58, 2DG3, 2DG4, 2DG9, 2FAP, 2VCD, 3KZ7, 4DRH, 4DRI, 4DRJ, 4QT2, 4QT3, 5FLC, 5GPG, 5HKG, 6M4U, 6M4V, 6M4W
1torin-149836027
pyridinonequinoline
608_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA19150980NANA
2torin-251358113
pyridinonequinoline
432_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA23436801NA4JSX
8PP242 / torkinib135565635
pyrazolopyrimidine
308_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA20686120NA4JT5
9MLN0128 / INK128 / TAK-228 / sapanisertib45375953benzoxazole309_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA6GVF, 6GVI
10AZD2014 / vistusertib25262792
phenylpyridine
463_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA23375793NA
11AZD805525262965
phenylpyridine, vistusertib analog
466_mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA23375793NA
3NVP-BEZ235 / dactolisib11977753
phenylquinoline
470PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA18606717NA
12voxtalisib / SAR245409 / XL76516123056
pyrazolylpyridine
270PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA24634413USA 6, EU 3NA
13LY3023414 / samotosilib57519748
imidazoquinoline
407PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA27439478NA
27wortmannin312145steroid428PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA8895571NA
1E7U, 3D5X, 3HHM
14LY2940023973
morpholine derivative
307PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA8895571NA
1E7V, 1YI3, 4AZT, 4CFK, 6G0D
28PQR309 / bimiralisib58507717pyridinamine411PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA29066507USA 8, EU 5
5JHB, 5OQ4, 6OAC
15gedatolisib / PKI-587 / PF0521238444516953
benzoylpiperidine
616PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA20166697NA
4GSK2126458 / omipalisib25167777quinoline506PI3K/mTORI, (E)
ATP-competitive mTOR inhibitor; 4E-BP1 activation and suppression of cap-dependent translation, primarily 5'-TOP mRNA
NA24900173USA 33L08
16МK1775 / adavosertib24856436piperazine501GCN2?I
GCN2 activator?, suppresses translation of 5’-TOP mRNA
NA30224479
5V5Y, 5VD0, 5VD4, 5VD5, 5VD7, 5VD8, 5VD9, 5VDA, 5VDK
17dabrafenib44462760sulfanilide520GCN2?I
GCN2 activator?, suppresses translation of 5’-TOP mRNA
NA30224479
4XV2, 5CSW, 5HIE, 6HJ2
29BTdCPU49787174
N,N'-diarylurea
339HRII
activator of HRI - kinase of initiation factor elF2; it leads to eIF2 inactivation
NA21765405NANA
5CCT0203123108148quinoline650PERKI
activator of PERK - kinase of initiation factor elF2; it leads to eIF2 inactivation
NA22253692NANA
30MK-2844265590
methylaminopentanamide
317PERKI
activator of PERK - kinase of initiation factor elF2; it leads to eIF2 inactivation
NA32327686NANA
18salubrinal5717801480
GADD34/PP1, CReP/PP1
I
inhibitor of eIF2-specific PP1 phosphatase complexes (GADD34/P1, CReP/P1), it leads to inactivation of eIF2
NA15705855NANA
19Sal0035717737462
GADD34/PP1, CReP/PP1
I
inhibitor of eIF2-specific PP1 phosphatase complexes (GADD34/P1, CReP/P1), it leads to inactivation of eIF2
NA17418795NANA
31ISRIB1011240
cyclohexylacetamide
451eIF2BI
eIF2B activity modulator; prevent translation inhibition
NANA
6CAJ, 6EZO, 6O81, 6O85
25myriaporone 371306325
polyketide, tedanolide group
373eEF2K?E
binds to eEF2K and induces phosphorylation and inactivation of eEF2
23303710NANA
26myriaporone 4100917959
polyketide, tedanolide group
373eEF2K?E
binds to eEF2K and induces phosphorylation and inactivation of eEF2
23303710NANA
32NH12510436839
methylimidazolium iodide
525eEF2K?E
eEF2 phosphorylation inductor
it was initially assumed to be an eEF2K inhibitor
NANA
20A-48495414998470
pyrimidine-6-carboxamide
289eEF2KE
inhibitor of eEF2K; prevent translation inhibition
NA22020937NANA
3365110
ribonucleotide
338AMPKE
AMPK activator; activates AMPK without changing the levels of the nucleotides
NA7926017NA
1M9N, 1P4R, 1PL0, 2CNQ, 2NTL, 2QRE, 2R7K, 2R7L, 2R7N, 2R84, 2UV5, 4A1O, 4TX9, 4XW7, 4XWF, 4ZNP, 5BTP, 5DN1, 5NXA, 5PZW, 5UY8, 5UZ0, 6OD9
6A-76966254708532NA360AMPKE
AMPK activator; activates AMPK by mimicking both effects of AMP, i.e. allosteric activation and inhibition of dephosphorylation
NA17855357NA4CFF
7"991"45256693
benzimidazole derivative
432AMPKE
AMPK activator;
also enhances AMPK activity in combination with AICAR
27577855NA4CFE, 5ISO


Diagram of the eukaryotic translational cycle, selected regulatory pathways, and the most commonly used and well-characterized inhibitors of protein synthesis


image/svg+xml RAS RAF MEK ERK AKT PI3K PTEN S6K1 PKR GCN2 HRI 3' 4E-BP1 4E-BP1 MNK1/2 PPM1G 80S IC 48S PIC 43SIC eIF4F Peptidebond formation Translocation